Enamine Ltd.

Looking for a new simple way to navigate through Enamine REAL and Chemspace Freedom Spaces? Use Hyperspace! It is a fantastic search tool created by our partners from Alipheron. Install Hyperspace plugin in your DataWarrior, draw or paste the query molecule, choose from super-structure or similarity search options, and receive your results in a blink of an eye! https://lnkd.in/duNVPfqg

Azepane linker in selective covalent BTK inhibitors can exhibit biochemical inhibitory potency in the picomolar range (BTK IC50 = 0.5 nM) and efficient covalent binding (BTK log kinact/Ki = 4.43) while maintaining favorable CNS-drug-like properties and low MDR1 efflux. Furthermore, they can exhibit improved selectivity for BTK relative to the nine active site cysteine-containing kinases(https://lnkd.in/dKfMcJaP). Try our azepanes building blocks in your research! https://lnkd.in/dZeySnSU

The process of abnormal accumulation of lipids in hepatocytes (also known as steatosis) is one of the signs of drug-induced liver injury (DILI). 𝘐𝘯 𝘷𝘪𝘵𝘳𝘰 steatosis assessment could be valuable information before initiating 𝘪𝘯 𝘷𝘪𝘷𝘰 studies of the drug-candidates. Bienta (Enamine Biology Services) offers an automated High Content Imaging assay to investigate the development of steatosis and detect the risk of drug-induced hepatotoxicity. The assay could be also multiplexed with the markers of your choice. Check the assay leaflet for more details: https://jmp.sh/SOQjSFIT Please, feel free to contact us at https://lnkd.in/djA-MUJH to inquire about the service. 

Urea functionality is incorporated to modulate drug potency and selectivity and improve drug properties in the development of anticancer, antibacterial, anticonvulsive, anti-HIV, antidiabetic agents, and other medicinal compounds. In 2011 Bogolubsky et al. proposed a powerful method for the synthesis of various unsymmetrically disubstituted urea derivatives using trifluoroethyl carbamates (https://lnkd.in/gGTWCGvw). Try our trifluoromethyl carbamate building blocks in your research! https://lnkd.in/gKveV84h

We are excited to participate in the 2nd Interdisciplinary Conference on Drug Sciences, ACCORD 2024, from May 23 to 25 in Warsaw, Poland. The goal of the conference is to integrate scientific and industrial communities involved at different stages of drug research and development. The motto of the Conference, ”Pharmaceutical innovations across the borders", provides an opportunity to explore scientific achievements in the field of drug science beyond the traditional scopes of scientific disciplines. Schedule a one-on-one meeting with us to discuss partnership opportunities and stay up to date on our latest innovations: https://lnkd.in/dmy3_9ac Event information: https://accord.wum.edu.pl

We are excited to announce a new partnership between Enamine and CALICI! Pharmaco-Net, a web-based cloud platform developed by Calici, now features our extensive Screening compounds catalog. This integration allows for seamless virtual searches with direct links to EnamineStore enabling the users to order the molecules of interest swiftly. https://lnkd.in/d-W83xYE

Please welcome Vitalii Datsiuk - the chemist behind the molecule of this week. Congratulations! 👏  https://bit.ly/4bbhfqn #Enamine #molecule #chemistry #science #drugdiscovery 

Imidazo[4,5-b]pyridines are known for showing antagonistic activity of various biological receptors including angiotensin-II, platelet-activating factor (PAF), subtypemetabotropic glutamate V3, AT1 receptor, and adenosine A2a. The imidazo[4,5-b]pyridine heterocyclic system is also a structural analog of purine, derivatives of which readily interact with large biomolecules such as DNA, RNA, and proteins in vivo. In a recent paper, John L. Kane, Jr. et al. describe the identification of selective CSF1R inhibitors based on the imidazo[4,5-b]pyridine scaffold (https://lnkd.in/dg9KZw98). Try our imidazo[4,5-b]pyridine building blocks in your research! https://lnkd.in/dXSe3-Xt

Thietane dioxide is a heterocyclic analogue of cyclobutane that significantly reduces lipophilicity while only modestly increasing molecular size. It serves as an excellent substituent for use in screening molecules. Enamine offers an interesting collection of compounds containing this molecular fragment: https://bit.ly/3y0TkeN Try our thietane dioxides in your research!

Pharmacelera and Enamine have announced the extension of their current partnership to explore an extraordinary magnitude of compounds, that has been extended by a 10 fold factor - when compared to the early version. Ultra-large chemical libraries constitute a key paradigm to tap into new and still unexplored chemical spaces, increasing the probability for the researcher to find new and chemically diverse potent hits for Discovery Programs. Efficient handling of the ultra-large compound libraries still remains the main challenge. Read full Press Release: https://bit.ly/3wrGBkN